DSE — Dermatan sulfate epimerase
DSE belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DSE's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Interferon Response Anti-viral | ACAP1, ARHGAP15, BCL2, CD44, CD46, EML4, FCGR2B, GATAD1 +7 more | View in SCUBA |
| CD4⁺ T cells | Cytokine signaling Immune regulation | ABCB1, ARHGEF40, AUTS2, COLQ, ERN1, GPR65, IFI44, IFNGR1 +12 more | View in SCUBA |
| Fibroblasts | Intestinal Fibroblast Identity Developmental | ABR, AFF3, ATP8A1, ATP9A, CAMK4, ENPP2, GLP2R, MRPS6 +7 more | View in SCUBA |
| Macrophages | Macrophage Endocytic Signaling Lysosomal & pahgocytosis | APLP2, ARHGAP30, ARHGEF2, ATF6B, BAG6, CLSTN1, CMTR2, CTBS +20 more | View in SCUBA |
| Monocytes | TNF-driven Activation Inflammatory | ATP13A3, CD44, DCUN1D3, GK, IVNS1ABP, LAMB3, LITAF, POMP +3 more | View in SCUBA |
| Mucosal-associated invariant T cell | MAIT Cell Identity T cell maturation | AFF3, DDX3Y, DKK3, EPAS1, FKBP5, FYN, GLIPR1, H1-10 +16 more | |
| Neutrophils | NF-κB Signaling Inflammatory | ATP13A3, BMP6, DOCK4, FLT1, HIVEP2, IRAK2, KIFC3, MAML2 +2 more |
About the gene
| Synonyms | DS-Epi1, DSEPI, SART2 |
|---|---|
| Chromosome | 6: 116254173-116444861 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Isomerase |
Function
Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. Plays an important role in the biosynthesis of the glycosaminoglycan/mucopolysaccharide dermatan sulfate.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.