FLT1 — Fms related receptor tyrosine kinase 1
FLT1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FLT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T cell exhaustion Exhaustion | CD247, CD38, CD59, GAN, IKBKB, LAG3, LRBA, PTMS +3 more | View in SCUBA |
| Endothelial | Venous Endothelial Identity Endothelial cell development | ACE, ADARB1, CDC42EP1, CLSTN1, EMCN, GALNT18, GPRC5B, GSN +11 more | View in SCUBA |
| Monocytes | SPP1+ Inflammatory Macrophage Inflammatory | DOCK4, DUSP4, GPR137B, IL7R, INHBA, MMP14, NECTIN2, SDC2 +6 more | View in SCUBA |
| Neutrophils | NF-κB Signaling Inflammatory | ATP13A3, BMP6, DOCK4, DSE, HIVEP2, IRAK2, KIFC3, MAML2 +2 more | |
| Pericytes | Vascular Permeability Migration & adhesion | ABI3, GALNT18, ITGA6, NQO1, PLVAP, PRKCH, TM4SF18 | View in SCUBA |
About the gene
| Synonyms | FLT, VEGFR1 |
|---|---|
| Chromosome | 13: 28300346-28495145 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins |
| Molecular function | Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase |
| Biological process | Angiogenesis, Chemotaxis, Differentiation |
Function
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1. Phosphorylates PLCG. May function as decoy receptor for VEGFA. May function as decoy receptor for VEGFA. May function as decoy receptor for VEGFA. Has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.