MAML2 — Mastermind like transcriptional coactivator 2
MAML2 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MAML2's module in each cell type
About the gene
| Synonyms | KIAA1819, MAM3 |
|---|---|
| Chromosome | 11: 95976598-96343195 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Activator |
| Biological process | Notch signaling pathway, Transcription, Transcription regulation |
Function
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.