BNIP3L — BCL2 interacting protein 3 like
BNIP3L belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BNIP3L's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | RNA Processing Regulation Housekeeping | ACBD3, AQR, ARCN1, BFAR, CCNI, CCNK, DIS3, DNAJC3 +15 more | View in SCUBA |
| Smooth muscle cells | XBP1 UPR Response Protein processing & ER | ADAMTS10, AKAP13, ATP1A1, BATF3, CHRD, DLC1, HERPUD1, MICAL1 +5 more | View in SCUBA |
About the gene
| Synonyms | BNIP3a, Nix |
|---|---|
| Chromosome | 8: 26383054-26505636 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted membrane proteins, Transporters |
| Biological process | Apoptosis, Host-virus interaction |
Function
Induces apoptosis. Interacts with viral and cellular anti- apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.