DNAJC3 — DnaJ heat shock protein family (Hsp40) member C3
DNAJC3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DNAJC3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | ER-Golgi Trafficking Vesicular traficking | ARL1, CALR, COPE, EMC7, GDI2, MPG, MYDGF, PDIA6 +6 more | View in SCUBA |
| Goblet cells | ER Protein Translocation Protein processing & ER | LMAN1, PDIA6, RPN2, SPCS2, SPCS3, SSR1, TMED10, TMED2 | View in SCUBA |
| Macrophages | RNA Processing Regulation Housekeeping | ACBD3, AQR, ARCN1, BFAR, BNIP3L, CCNI, CCNK, DIS3 +15 more | View in SCUBA |
About the gene
| Synonyms | ERdj6, HP58, P58, p58(IPK), P58IPK, PRKRI |
|---|---|
| Chromosome | 13: 95677139-95794988 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Chaperone, Repressor |
| Biological process | Antiviral defense, Stress response, Translation regulation, Unfolded protein response |
Function
Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF- 2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.