DLC1 — DLC1 Rho GTPase activating protein
DLC1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DLC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Stress Response Stress | CRK, GCLM, IFT20, KRAS, ODC1, SBDS, SERP1, SERPINH1 +7 more | View in SCUBA |
| Fibroblasts | Inflammatory Fibroblast Activation Inflammatory | ATP2A2, BAMBI, C5AR2, CRISPLD2, CSNK1E, CTNNB1, ETS2, F2RL3 +11 more | View in SCUBA |
| Hematopoietic progenitor cells | HPC Stemness Program Stemness | AMHR2, ARMC8, CASP3, CITED2, CNRIP1, CSF2RB, FBXO7, HBS1L +3 more | |
| Smooth muscle cells | XBP1 UPR Response Protein processing & ER | ADAMTS10, AKAP13, ATP1A1, BATF3, BNIP3L, CHRD, HERPUD1, MICAL1 +5 more | View in SCUBA |
About the gene
| Synonyms | ARHGAP7, DLC-1, HP, p122-RhoGAP, STARD12 |
|---|---|
| Chromosome | 8: 13083361-13604610 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | GTPase activation |
Function
Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85. The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.