HERPUD1 — Homocysteine inducible ER protein with ubiquitin like domain 1

HERPUD1 belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

HERPUD1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	NF-kB signaling BCR/AP1/NFKb pathway	ARIH1, BACH1, BRAF, MTMR6, RAB21, RASGEF1B, REL, RNMT +5 more	View in SCUBA
CD4⁺ T cells	IL6-STAT3 Signaling Intercellular communication	ARID5A, ARL6IP1, AZIN1, CCDC66, CDC40, CEMIP2, CHD1, CSNK1D +13 more	View in SCUBA
Gamma-delta T cells	NF-κB Activation Inflammation	DUSP5, GADD45A, IL21R, KDM6B, MAFF, NAMPT, NFKB1, NFKB2 +13 more
Goblet cells	ERAD ER Homeostasis Protein processing & ER	ARF4, ATP2A2, C1orf122, DNAJB9, JTB, LARP1B, PGM3, SELENOK +1 more	View in SCUBA
Hematopoietic progenitor cells	Dendritic Cell Progenitor Myeloid development	BLNK, CCDC50, CD180, CLEC4A, HDAC9, IRF8, LY86, NCF1 +1 more
Innate lymphoid cells	Integrated Stress Response Stress	AMD1, ATF4, CYCS, DDX5, DNAJB6, EIF1, GPBP1, HNRNPH1 +3 more	View in SCUBA
Macrophages	Anti-inflammatory Response Inflammatory	AMPD2, ARRDC2, BHLHE40, CBX4, CDKN1B, CEBPD, CITED2, DENND3 +31 more	View in SCUBA
Mucosal-associated invariant T cell	ER Stress UPR Stress	DDIT3, DNAJB9, EIF4A1, GTF2B, HNRNPA0, IDI1, LDHA, MAP1LC3B +9 more
Natural Killer cells	ER Stress Response Stress	ARF4, CYCS, DNAJB6, EIF4A3, EIF5, GADD45B, SAP18, SERTAD1	View in SCUBA
Smooth muscle cells	XBP1 UPR Response Protein processing & ER	ADAMTS10, AKAP13, ATP1A1, BATF3, BNIP3L, CHRD, DLC1, MICAL1 +5 more	View in SCUBA

About the gene

Synonyms	HERP, KIAA0025, Mif1, SUP
Chromosome	16: 56932142-56944864
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Biological process	Unfolded protein response

Function

Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin- mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.