RNA Processing Regulation
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 24 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 24 genes have a known function matching the annotation |
Why this annotation
Hub genes include TAX1BP1 (ubiquitin-binding autophagy adaptor), GRB2 (signaling adaptor), TERF2IP (telomere/NF-κB), FYTTD1 (mRNA export), DNAJC3 (ER stress co-chaperone), CCNI/CCNK (cyclins), DIS3 (RNA exosome subunit), EIF4H (translation initiation), AQR (splicing helicase), ELOA (transcription elongation). The module combines RNA processing (DIS3, AQR, FYTTD1, EIF4H), transcription regulation (ELOA, CCNK, CCNI), and signaling (GRB2, PAK2, PTP4A2). This is a broadly mixed housekeeping/regulatory module with no single dominant pathway. The RNA processing genes are the most coherent sub-theme.
Genes
ACBD3, AQR, ARCN1, BFAR, BNIP3L, CCNI, CCNK, DIS3, DNAJC3, EIF4H, ELOA, ERLEC1, ETF1, FYTTD1, GRB2, IBTK, MGAT1, MKRN1, PAK2, PTP4A2, SPTY2D1, TAX1BP1, TERF2IP, TRIM44
Most correlated modules
- Ubiquitin-ERAD Proteostasis · correlation 0.98
- RNA Splicing Regulation · correlation 0.98
- mRNA Splicing Processing · correlation 0.96
- General Cellular Maintenance · correlation 0.96
- ER Membrane Homeostasis · correlation 0.96
- ER-Golgi Trafficking · correlation 0.95
- Endolysosomal Trafficking · correlation 0.95
- RAS-MAPK Signaling · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.