SCUBA

ACTG1 — Actin gamma 1

ACTG1 belongs to a gene co-expression module in 12 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ACTG1's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsActin Cytoskeleton
Cytoskeletal
ACTB, ACTR3, ARPC1B, ARPC2, ARPC4, ARPC5, BRK1, CAP1 +14 moreView in SCUBA
CD4⁺ T cellsActin cytoskeleton
Cytoskeletal
ACTB, ARPC2, ARPC3, CLIC1, COPE, ELOB, GAPDH, PFN1 +3 moreView in SCUBA
CD8⁺ T cellsActin Cytoskeleton Dynamics
Cytoskeletal
ACTR3, ANXA11, ARPC2, CAP1, CDK2AP2, RAC2, RNF181View in SCUBA
EndothelialActin Cytoskeletal Remodeling
Cytoskeletal
ACTB, ARF1, ARPC5L, CFL1, CYCS, DNAJB11, DNAJC1, ERLEC1 +5 moreView in SCUBA
EnterocytesActin cytoskeleton
Cytoskeletal
ACTB, CAST, CDC42EP5, CLDN7, JPT1, MYL12B, PIGR, TMEM54View in SCUBA
Gamma-delta T cellsmRNA Splicing
RNA processing & translation
ACTB, ACTL6A, ACTR3, AK2, BRD8, CASP2, CCDC14, CCT5 +13 more
Glial cellsActin Cytoskeletal Organization
Cytoskeletal
ACTB, CALM1, CFL1, CIRBP, DYNLL1, ELOC, MORF4L2, PPIA +1 moreView in SCUBA
Goblet cellsBasal Transcription
Housekeeping
ACTB, CALM2, DYNLL1, ELOC, ENY2, GTF2A2, LSM8, POLR2K +2 moreView in SCUBA
Innate lymphoid cellsActin Cytoskeleton Dynamics
Cytoskeleton & motility
ACTB, ACTR3, ANAPC11, AP2S1, ARPC5, CALM3, CAPZB, LDHA +11 moreView in SCUBA
Mucosal-associated invariant T cellActin Cytoskeletal Dynamics
Cytoskeletal
ACTB, CLIC1, CORO1A, CSK, CTSC, NHERF1, PPP1CA, RAC2 +2 more
Natural Killer cellsNK Cell Activation
activation
ACTR2, ACTR3, CD38, LCP1, LNPEP, MSN, TLN1, XPO1View in SCUBA
NeutrophilsActin Cytoskeleton Dynamics
Cytoskeletal
ACTB, ARPC5, CFL1, CORO1A, ITGB2, MYL6, PFN1, RGL4 +6 more

About the gene

SynonymsACTG, DFNA20, DFNA26
Chromosome17: 81509413-81523847
Predicted locationIntracellular
Essential geneYes
Protein classDisease related genes, Essential proteins, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Molecular functionHydrolase

Function

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. May play a role in the repair of noise-induced stereocilia gaps thereby maintains hearing sensitivity following loud noise damage (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.