AK2 — Adenylate kinase 2
AK2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AK2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | mRNA Splicing RNA processing & translation | ACTB, ACTG1, ACTL6A, ACTR3, BRD8, CASP2, CCDC14, CCT5 +13 more | |
| Innate lymphoid cells | Ubiquitin Stress Response Stress | AIP, AP2A1, ARMC10, GPAA1, IAH1, NSFL1C, PHF5A, TRADD +2 more | View in SCUBA |
| Macrophages | ER Protein Glycosylation Vesicular traficking | ALG3, ALG5, BABAM1, CKLF, CRELD2, DDOST, DPM3, FAM136A +21 more | View in SCUBA |
About the gene
| Chromosome | 1: 33007986-33080996 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Kinase, Transferase |
Function
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.