mRNA Splicing
Gene co-expression module in Gamma-delta T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 22 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 22 genes have a known function matching the annotation |
Why this annotation
Top hub genes HNRNPF and HNRNPA2B1 are core hnRNP splicing regulators with core membership. SF3A3 (U2 snRNP splicing factor), SRPK1 (SR protein kinase regulating splicing), and PRPF6 (pre-mRNA splicing factor) further anchor RNA splicing. ACTR3 (ARP3), ACTB, and ACTG1 (beta/gamma actin) contribute cytoskeletal components, while XPO1 (nuclear export) and COPB2 (COPI coat) represent transport. The dominant hnRNP hub genes with core membership and multiple additional splicing factors support mRNA splicing as the primary program.
Genes
ACTB, ACTG1, ACTL6A, ACTR3, AK2, BRD8, CASP2, CCDC14, CCT5, COPB2, DCAF7, GDI2, HDAC2, HNRNPA2B1, HNRNPF, POP5, SF3A3, SRBD1, SRPK1, TRIM56, URM1, XPO1
Most correlated modules
- DNA Damage Repair · correlation 0.89
- Mitotic Spindle · correlation 0.85
- Interferon Stimulated Response · correlation 0.85
- Rho GTPase Signaling · correlation 0.81
- Cellular Homeostasis · correlation 0.79
- Chromatin TF Regulation · correlation 0.78
- Mitoribosome Small Subunit · correlation 0.78
- T cell Survival · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.