RBM15B — RNA binding motif protein 15B
RBM15B belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RBM15B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | mRNA Splicing Processing RNA processing & translation | ARHGEF1, BECN1, CCNI, DENND4B, EID1, HNRNPA0, HNRNPDL, KLHDC4 +18 more | |
| Macrophages | RNA Processing Housekeeping Housekeeping | CISD3, CNIH4, DDX52, DPH3, EXOSC6, FABP5, GTF2E2, IKBKE +20 more | View in SCUBA |
| Mucosal-associated invariant T cell | mRNA 3' Processing RNA processing & translation | ATXN2L, CD6, DNM2, EIF4A2, HNRNPDL, MLLT6, NOP58, RNF10 +3 more |
About the gene
| Synonyms | HUMAGCGB, OTT3 |
|---|---|
| Chromosome | 3: 51391285-51397908 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | RNA-binding |
| Biological process | Host-virus interaction, mRNA processing, mRNA splicing, Transcription, Transcription regulation |
Function
RNA-binding protein that acts as a key regulator of N6- methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA. Associated component of the WMM complex, a complex that mediates N6- methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex. Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist. Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation. Inhibits pre-mRNA splicing. Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.