mRNA 3' Processing
Gene co-expression module in Mucosal-associated invariant T cell
| Category | RNA processing & translation |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 12 genes have a known function matching the annotation |
Why this annotation
Top hubs ATXN2L (RNA granule/stress granule assembly, translational regulation), ZNF800 (transcription repressor), RNF10 (ubiquitin E3 ligase, transcription regulation), EIF4A2 (translation initiation helicase), NOP58 (box C/D snoRNP, rRNA processing), RBM15B (RNA binding, m6A methylation writer complex), WDR33 (mRNA 3'-end cleavage/polyadenylation), HNRNPDL (RNA binding), MLLT6 (chromatin, DOT1L complex), and UBE2J1 (ER-associated degradation E2). CD6 is a T cell surface receptor consistent with MAIT identity. DNM2 (dynamin 2) links to membrane/endosome. The dominant program is post-transcriptional RNA regulation including mRNA 3' processing, translation, and RNA granule biology.
Genes
ATXN2L, CD6, DNM2, EIF4A2, HNRNPDL, MLLT6, NOP58, RBM15B, RNF10, UBE2J1, WDR33, ZNF800
Most correlated modules
- Nuclear Receptor Chromatin · correlation 0.87
- TGF-beta Response · correlation 0.83
- Co-transcriptional Splicing · correlation 0.83
- Transcription Factor Activity · correlation 0.82
- Housekeeping Translation · correlation 0.78
- Autophagy & Trafficking · correlation 0.78
- Cytoskeletal Organization · correlation 0.78
- mRNA Decay Program · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.