CEP250 — Centrosomal protein 250
CEP250 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CEP250's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Actin Cytoskeletal Regulation Cytoskeletal | ACTR2, AP3B1, AP3M1, AZI2, CAPZA1, CPSF3, DIDO1, DOCK8 +25 more | |
| Mucosal-associated invariant T cell | Circadian Transcriptional Regulation DNA/chromatin regulation | ABCB1, ANKRD12, ATOSA, BMAL1, GCC2, MIA3, MIER1, NCOA7 +2 more |
About the gene
| Synonyms | C-NAP1, CEP2 |
|---|---|
| Chromosome | 20: 35455164-35519280 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Cell cycle, Cilium biogenesis/degradation |
Function
Plays an important role in centrosome cohesion during interphase. Recruits CCDC102B to the proximal ends of centrioles. Maintains centrosome cohesion by forming intercentriolar linkages. Accumulates at the proximal end of each centriole, forming supramolecular assemblies with viscous material properties that promote organelle cohesion. May be involved in ciliogenesis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.