MIA3 — MIA SH3 domain ER export factor 3
MIA3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MIA3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | DNA repair/replication DNA/chromatin regulation | ACAP2, BROX, CCDC88C, CKAP2, EPM2AIP1, FOXO3, HAUS3, HELB +4 more | View in SCUBA |
| Goblet cells | Golgi-Exocytosis Machinery Mucus production & secretion | BCAS1, GALNT5, GOLGA2, GOLGA3, MLPH, PLA2G10, RRBP1, SEC31A +2 more | View in SCUBA |
| Mucosal-associated invariant T cell | Circadian Transcriptional Regulation DNA/chromatin regulation | ABCB1, ANKRD12, ATOSA, BMAL1, CEP250, GCC2, MIER1, NCOA7 +2 more |
About the gene
| Synonyms | FLJ39207, KIAA0268, TANGO, TANGO1, UNQ6077 |
|---|---|
| Chromosome | 1: 222618097-222668007 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters |
| Biological process | ER-Golgi transport, Exocytosis, Protein transport, Transport |
Function
Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum. Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER- resident complexes consisting of MIA2 and PREB/SEC12 to ERES.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.