MIER1 — MIER1 transcriptional regulator
MIER1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MIER1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Chromatin regulation DNA/chromatin regulation | ANKRD11, BIRC6, CNTRL, EP300, FAM118A, GOLGA4, IRF2, KAT6A +12 more | View in SCUBA |
| Gamma-delta T cells | T Cell Migration migration & adhesion | BCL2, BPNT2, CCDC88B, DNM2, EDC4, GMDS, LRRC58, MARK3 +14 more | |
| Innate lymphoid cells | Golgi RNA Processing RNA processing & translation | ANKRD12, ATM, DDX17, GCC2, GOLGA4, LUC7L3, MLEC, MYCBP2 +11 more | View in SCUBA |
| Macrophages | RAS-MAPK Signaling Housekeeping | ARF4, ATG12, CAMTA1, CDC37, CHMP4B, ETFA, GLA, HMGA1 +26 more | View in SCUBA |
| Mucosal-associated invariant T cell | Circadian Transcriptional Regulation DNA/chromatin regulation | ABCB1, ANKRD12, ATOSA, BMAL1, CEP250, GCC2, MIA3, NCOA7 +2 more |
About the gene
| Synonyms | hMI-ER1, KIAA1610, MI-ER1 |
|---|---|
| Chromosome | 1: 66924895-66988619 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.