Actin Cytoskeletal Regulation
Gene co-expression module in Gamma-delta T cells
| Category | Cytoskeletal |
|---|---|
| Genes | 34 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 14 of 34 genes have a known function matching the annotation |
Why this annotation
Hub genes include USP33 (deubiquitinase), CEP250 (centrosomal), ACTR2 (Arp2/3 complex, actin nucleation), CAPZA1 (actin capping), NBR1 (autophagy receptor/ubiquitin binding), POLR2B (RNA Pol II subunit), KDM5A (histone H3K4 demethylase), SRSF4 (splicing), CPSF3 (mRNA 3' processing), EIF3A (translation initiation), DOCK8 (Rho GEF). The module is strongly coherent with uniform expression. Multiple actin cytoskeletal regulators (ACTR2, CAPZA1) co-expressed with ubiquitin pathway (USP33, NBR1), transcription (POLR2B, KDM5A), and RNA processing (SRSF4, CPSF3, SCAF11, RBM6) genes reflect a broad cellular homeostasis program. The actin nucleation/capping genes (ACTR2/CAPZA1) are the most coherent cytoskeletal signal. Neighbor context: shares actin/cytoskeletal theme with M178 (IQGAP1, MAP4) and Rho signaling in M72. The co-expression of diverse housekeeping functions likely reflects a general transcriptional activity state in a subset of gd_T cells.
Genes
ACTR2, AP3B1, AP3M1, AZI2, CAPZA1, CEP250, CPSF3, DIDO1, DOCK8, EIF3A, ERCC5, KDM5A, LNPEP, MEF2A, NBR1, NUP107, PDCD6IP, PML, POLR2B, PPP1R12A, PRKD3, RBM6, SCAF11, SLC16A7, SP4, SRSF4, TMEM87B, TMX3, TPR, USP33, WASHC5, ZNF148, ZNF740, ZNF91
Most correlated modules
- Rho GTPase Signaling · correlation 0.91
- DNA Damage Response · correlation 0.89
- Chromatin Remodeling · correlation 0.89
- mTOR-Exocyst Signaling · correlation 0.87
- Metabolic-Translational Coupling · correlation 0.87
- Vesicular Trafficking · correlation 0.86
- Interferon Antiviral Response · correlation 0.85
- Immune Negative Regulation · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.