Circadian Transcriptional Regulation
Gene co-expression module in Mucosal-associated invariant T cell
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
BMAL1 (core circadian clock transcription factor), MIER1 (transcriptional repressor), ANKRD12 (ankyrin repeat transcriptional corepressor), NCOA7 (nuclear receptor coactivator with antiviral functions), ABCB1 (P-glycoprotein/MDR1 efflux transporter, expressed in memory/regulatory T cells), UBE4A (ubiquitin chain elongation), MIA3/TANGO1 (ER exit/secretion), GCC2 (Golgi), CEP250 (centrosomal), and NKTR collectively suggest a module centered on circadian-regulated transcriptional repression and cellular homeostasis. BMAL1 is the most specific anchor; its co-expression with repressors MIER1 and ANKRD12 suggests circadian transcriptional regulation. ABCB1 is associated with T cell memory and efflux.
Genes
ABCB1, ANKRD12, ATOSA, BMAL1, CEP250, GCC2, MIA3, MIER1, NCOA7, NKTR, UBE4A
Most correlated modules
- Cellular Maintenance · correlation 0.82
- T cell Homeostasis · correlation 0.81
- TCR Activation Signaling · correlation 0.81
- Cytoskeletal Organization · correlation 0.80
- SWI/SNF Chromatin Remodeling · correlation 0.79
- TCR Signal Attenuation · correlation 0.76
- Nuclear-Cytoskeletal Organization · correlation 0.75
- T cell Activation Signaling · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.