CAPZA1 — Capping actin protein of muscle Z-line subunit alpha 1
CAPZA1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CAPZA1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Actin cytoskeleton remodeling Cytoskeletal | ACTR2, BASP1, CDV3, EIF3A, FAM107B, GRB2, HCLS1, LIMS1 +9 more | View in SCUBA |
| CD4⁺ T cells | Interferon response Anti-viral | ACTN4, CHMP4A, CHMP5, EFHD2, IL12RB1, LSP1, PARP14, PIN1 +7 more | View in SCUBA |
| Gamma-delta T cells | Actin Cytoskeletal Regulation Cytoskeletal | ACTR2, AP3B1, AP3M1, AZI2, CEP250, CPSF3, DIDO1, DOCK8 +25 more | |
| Innate lymphoid cells | Proteasome & TCA Protein processing & ER | ACP1, ARPC5L, CLTA, COPS9, HDAC1, MDH2, NDUFA1, NUDT16L1 +5 more | View in SCUBA |
| Macrophages | ER Membrane Homeostasis Housekeeping | ATP6V1A, BNIP2, CANX, CD164, CMTM6, COPB1, EXOC5, GFM1 +18 more | View in SCUBA |
| Mucosal-associated invariant T cell | Vesicle Membrane Trafficking Housekeeping | ACSL5, AP2B1, APOBR, CAPRIN1, DDX23, G3BP1, IARS1, PITPNB +6 more |
About the gene
| Chromosome | 1: 112619805-112671616 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Actin capping, Actin-binding |
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.