ITGA9 — Integrin subunit alpha 9
ITGA9 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ITGA9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Integrin-Actin Adhesion migration & adhesion | APP, CHD3, CTNNA1, DAG1, DOCK6, FKBP9, FMNL3, ITGB1 +6 more | View in SCUBA |
| Fibroblasts | BMP-Wnt Niche Signaling Developmental | CHMP4C, DCAF12L1, DIRAS1, DPEP2, GIPC3, LUZP2, MSTN, MYEF2 +8 more | View in SCUBA |
| Macrophages | Macrophage Migration Migration & adhesion | CEMIP2, CPM, EPB41L2, EPS8, GBE1, KCNQ1, MAN1A1, MEF2C +12 more | View in SCUBA |
| Monocytes | Complement C1q Macrophage Innate immunity | ACP2, C1QA, C1QB, C1QC, CLIC2, DNPH1, GFRA2, NR1H3 +4 more | View in SCUBA |
| Smooth muscle cells | Microfibril ECM Assembly ECM remodeling | ADAM28, FBN2, NEO1, NID1, PROM1, PSD3, SERPINE2, SPON1 +2 more | View in SCUBA |
About the gene
| Synonyms | ALPHA-RLC, ITGA4L, RLC |
|---|---|
| Chromosome | 3: 37452115-37823507 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Integrin, Receptor |
| Biological process | Cell adhesion |
Function
Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D- G-I-E-L in cytotactin. ITGA9:ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion (By similarity). Integrin ITGA9:ITGB1 represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via its interaction with SVEP1, thereby inhibiting vasocontraction.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.