FMNL3 — Formin like 3
FMNL3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FMNL3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Integrin-Actin Adhesion migration & adhesion | APP, CHD3, CTNNA1, DAG1, DOCK6, FKBP9, ITGA9, ITGB1 +6 more | View in SCUBA |
| Gamma-delta T cells | Redox Stress Response Stress | BEX2, BEX4, CITED4, EEF1A1, FTL, GRINA, LTBP3, MICAL1 +5 more | |
| Pericytes | Actin Cytoskeletal Remodeling Cytoskeletal | CDC42EP1, DPYSL2, ETS1, HDAC1, LXN, ORAI2, RAI14, SHC1 | View in SCUBA |
About the gene
| Synonyms | DKFZp762B245, MGC45819, WBP3 |
|---|---|
| Chromosome | 12: 49636499-49708165 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Developmental protein |
| Biological process | Angiogenesis |
Function
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis (By similarity). In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.