Integrin-Actin Adhesion
Gene co-expression module in Endothelial
| Category | migration & adhesion |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes ITGB1 (integrin β1), CTNNA1 (α-catenin), DOCK6 (Rac/Cdc42 GEF), FMNL3 (formin), SPTBN1 (spectrin), DAG1 (dystroglycan), and ITGA9 (integrin α9) collectively define an integrin-mediated adhesion and actin cytoskeletal remodeling program. S1PR1 is a key endothelial barrier receptor. Upregulation in both UC and CD inflammation suggests this program is activated during inflammatory endothelial remodeling. Neighbor context: shares cytoskeletal/adhesion themes with M69 and M43 but is more focused on integrin-actin linkage.
Genes
APP, CHD3, CTNNA1, DAG1, DOCK6, FKBP9, FMNL3, ITGA9, ITGB1, KLHL5, S1PR1, SPTBN1, TMEM50B, YWHAH, ZDHHC20
Most correlated modules
- WAVE Complex Cytoskeleton · correlation 0.90
- Mitophagy Stress Response · correlation 0.89
- Endothelial Angiogenic Identity · correlation 0.89
- Endothelial Junction Identity · correlation 0.88
- Actomyosin Contractility · correlation 0.86
- Chromatin Cell Cycle · correlation 0.84
- Endocytic Membrane Remodeling · correlation 0.82
- Arterial EC Identity · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.