LPXN — Leupaxin
LPXN belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LPXN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Rho-GTPase Migration migration & adhesion | ARHGAP18, ARHGEF7, FNBP1, HELZ, MAP4K1, MIS18BP1, PREX1, RORA +4 more | View in SCUBA |
| Gamma-delta T cells | Chaperone Protein Folding Protein processing & ER | AAMP, AHCYL1, CCT7, CCT8, CHMP5, COX17, DPY30, EIF2S2 +16 more | |
| Innate lymphoid cells | ILC1 Inflammatory Activation Inflammation | ALOX5AP, CNOT7, COMMD10, ELAVL1, FKBP8, FNTA, IFI27L2, IL32 +11 more | View in SCUBA |
| Macrophages | NRF2 Oxidative Stress Stress | ACOT9, AHRR, ARMC9, BASP1, CARD19, CCDC71L, CD226, CLDND1 +27 more | View in SCUBA |
| Mucosal-associated invariant T cell | MAIT Tissue Residence Tissue residence | ANAPC16, ARHGDIB, ATP5IF1, CD3E, CD53, CD99, CTSD, CXCR6 +7 more | |
| Natural Killer cells | NK Inflammatory Activation Inflammation | BST2, CCT4, FCER1G, FGFR1OP2, ITM2B, LPIN2, MBNL1, PTGES3 +1 more | View in SCUBA |
About the gene
| Synonyms | LDPL |
|---|---|
| Chromosome | 11: 58526871-58578220 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Activator |
| Biological process | Cell adhesion, Transcription, Transcription regulation |
Function
Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.