IL32 — Interleukin 32

IL32 belongs to a gene co-expression module in 12 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

IL32's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Inflammatory activation Immune regulation	ACP5, B2M, CALCOCO1, CCNG2, CHST11, CORO1A, HLA-A, PITPNM2 +10 more	View in SCUBA
CD8⁺ T cells	Cytotoxic Effector cytotoxicity	APOBEC3H, B2M, CCL4, CCL5, CD52, CYBA, GZMH, HCST +4 more	View in SCUBA
Enterocytes	Surface colonocyte lipid-droplet Lipid metabolism	ALPI, CDKN1A, CIDEB, CIDEC, LMO7, LPGAT1, MPP1, MUC17 +4 more	View in SCUBA
Fibroblasts	NF-κB Inflammatory Activation Inflammatory	BIRC3, CD40, CTSS, DRAM1, HAPLN3, IL15RA, LAP3, STAT1 +5 more	View in SCUBA
Gamma-delta T cells	Immune Synapse Cytoskeleton Cytoskeletal	ARHGAP4, ARHGAP45, ATP2A3, CD48, DDOST, ICAM3, LAPTM5, LTB4R2 +8 more
Glial cells	IFN-gamma Effector Program Inflammation	APOL1, APOL2, GBP1, IDO1, IFI44L, IL18BP, LAP3, ODF3B +5 more	View in SCUBA
Goblet cells	DUOX2 Epithelial Inflammation Stress	AKAP13, BIRC3, DUOX2, DUOXA2, DUSP4, IL2RG, ISG15, RNF213 +1 more	View in SCUBA
Innate lymphoid cells	ILC1 Inflammatory Activation Inflammation	ALOX5AP, CNOT7, COMMD10, ELAVL1, FKBP8, FNTA, IFI27L2, LPXN +11 more	View in SCUBA
Macrophages	IFN-gamma Response Inflammatory	ANKRD22, APOL2, ATF5, ATP13A1, CD274, CD300LF, CD40, CD48 +21 more	View in SCUBA
Mucosal-associated invariant T cell	Cyclophilin-Mediated Folding Housekeeping	B2M, BBLN, BCL7C, C12orf75, CFL1, EDF1, EIF3L, ERH +10 more
Pericytes	NF-κB Inflammatory Activation Inflammatory	CTSS, EFHD2, HIF1A, LAP3, OSMR, TAPBP, TMEM165	View in SCUBA
Smooth muscle cells	IFN-gamma/NF-kB Response Inflammation	ATP6V0B, CCDC71L, CFLAR, CHI3L2, EVA1B, GBP1, GBP2, HSPA8 +11 more	View in SCUBA

About the gene

Synonyms	NK4, TAIF, TAIFb, TAIFd
Chromosome	16: 3065297-3082192
Predicted location	Intracellular, Secreted
Essential gene	No
Protein class	Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Molecular function	Cytokine

Function

Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.