ILC1 Inflammatory Activation
Gene co-expression module in Innate lymphoid cells
| Category | Inflammation |
|---|---|
| Genes | 20 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 20 genes have a known function matching the annotation |
Why this annotation
This module has weak coherence and nearly all genes show weak membership, indicating a poorly defined mixed program. The most notable hub gene is IL32 (ILC1 7.7x enrichment), a pro-inflammatory cytokine produced by NK/ILC1 cells. ALOX5AP encodes FLAP (5-lipoxygenase activating protein), involved in leukotriene biosynthesis. TXK is a Tec-family kinase involved in T/NK cell activation. LPXN (leupaxin) and RSU1 are integrin/focal adhesion signaling proteins. ELAVL1 stabilizes mRNAs of cytokines. IFI27L2 is interferon-stimulated. UBE2D2 and XRCC6 are broadly expressed housekeeping genes. The ILC1 enrichment pattern and presence of IL32, ALOX5AP, TXK suggests a weak inflammatory/activation signature in ILC1 cells, but the module is too heterogeneous for high confidence. Neighbor context: shares ILC1 bias with M42 and M79 but lacks the clear OxPhos or translation programs of those modules.
Genes
ALOX5AP, CNOT7, COMMD10, ELAVL1, FKBP8, FNTA, IFI27L2, IL32, LPXN, NUCB1, NUTF2, OXNAD1, PERP, RAB11A, RSU1, SYPL1, TUBB, TXK, UBE2D2, XRCC6
Most correlated modules
- Glycolysis & OxPhos · correlation 0.95
- Actin Cytoskeleton Dynamics · correlation 0.94
- Mitochondrial OxPhos · correlation 0.94
- Ubiquitin Stress Response · correlation 0.93
- ILC1 Actin Motility · correlation 0.92
- ILC-1 identity · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.