HMGA1 — High mobility group AT-hook 1

HMGA1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

HMGA1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Chromatin Remodeling DNA/chromatin regulation	ANP32B, ATP5IF1, CALM3, CBX3, COMMD4, HAT1, HMGB1, HNRNPD +9 more	View in SCUBA
Gamma-delta T cells	Mitochondrial OxPhos Mitochondrial & OxPhos	ADSL, AP1S1, CD151, COMTD1, COX5A, DDT, DNPH1, DUSP23 +20 more
Goblet cells	Glutathione Detoxification Stress	EIF3K, GSTP1, HINT1, MGST1, MGST3, SLIRP, SNRPD2, TST +1 more	View in SCUBA
Innate lymphoid cells	ILC1 Cytoskeletal Metabolic Cytoskeleton & motility	ATP5F1B, ATXN10, CCT7, CD82, DNPH1, GADD45GIP1, MEA1, MTCH2 +14 more	View in SCUBA
Lymphatic endothelial	NF-κB Inflammatory Activation Inflammation	ACHE, ANKLE2, CD200, CXCL1, CXCL8, ICOSLG, NFKB2, NOD2 +9 more	View in SCUBA
Macrophages	RAS-MAPK Signaling Housekeeping	ARF4, ATG12, CAMTA1, CDC37, CHMP4B, ETFA, GLA, JAK1 +26 more	View in SCUBA
Monocytes	Secretory Vesicle Trafficking Vesicular traficking	ABHD17C, CTNNBL1, DHRS3, FAM20C, NRIP1, PCBP3, SEMA3F, STX1A +1 more	View in SCUBA

About the gene

Synonyms	HMGIY
Chromosome	6: 34236873-34246231
Predicted location	Intracellular
Essential gene	Yes
Protein class	Cancer-related genes, Disease related genes, Essential proteins, Predicted intracellular proteins, Transcription factors
Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Function

HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.