Chromatin Remodeling
Gene co-expression module in CD19⁺ B cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by nuclear chromatin and RNA-binding factors: ANP32B (histone chaperone), HMGA1/HMGB1/HMGN1-like high-mobility group proteins, HNRNPM/HNRNPD (hnRNPs), CBX3 (HP1-gamma), MBD2, HAT1 (histone acetyltransferase), NUCKS1, NUDT21. This is a proliferation-associated chromatin/RNA-processing program (many are markers of dividing cells). Uniform expression with no contaminating subset, core coherence. The mix of chromatin remodelers and hnRNPs reflects a broad nuclear biosynthetic/proliferative state rather than a single discrete pathway. Best fit is DNA/chromatin regulation given HMGA1, HMGB1, CBX3, MBD2, HAT1, PARP-like activity.
Genes
ANP32B, ATP5IF1, CALM3, CBX3, COMMD4, HAT1, HMGA1, HMGB1, HNRNPD, HNRNPM, MBD2, NDUFC1, NUCKS1, NUDT21, PPP4C, PRDX6, SKA2, YWHAE
Most correlated modules
- Mitochondrial Redox · correlation 0.98
- mRNA Splicing · correlation 0.96
- Oxidative Phosphorylation · correlation 0.96
- RNA Processing · correlation 0.95
- Cell Cycle Proliferation · correlation 0.95
- Cell Cycle G1/S · correlation 0.94
- Proteasome Complex · correlation 0.94
- DNA Replication · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.