Nuclear Transport
Gene co-expression module in Endothelial
| Category | Housekeeping |
|---|---|
| Genes | 27 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 27 genes have a known function matching the annotation |
Why this annotation
Top hub CSE1L is the exportin for importin-alpha, a key nuclear export factor. KPNB1 is importin-beta-1 (nuclear import). IPO5 is importin-5. MZT2A is a microtubule nucleation factor (gamma-TuRC). SMC1A is a cohesin subunit. SSRP1 is a FACT complex chromatin remodeler. TFDP1 is a DP transcription factor (E2F partner). NUCKS1 is a chromatin regulator. TRIM28 is a transcriptional corepressor. DEK is a chromatin/RNA-binding protein. LSM4/SNRPC are spliceosome components. DAZAP1 is an RNA-binding protein. HDGF is a growth factor. COMMD4 is a COMM domain protein. COQ2 is coenzyme Q biosynthesis. PRKCSH is a glucosidase. AAMDC is a small adaptor. The module is dominated by nuclear transport (CSE1L, KPNB1, IPO5) and chromatin/cell-cycle regulators (SMC1A, SSRP1, TFDP1, NUCKS1, TRIM28, DEK), with spliceosome and RNA-binding components. Upregulated in inflammation, reversed in remission. Neighbor context: adjacent to M102 (RAN-centered nuclear transport) and cell-cycle modules, supporting a proliferation/nuclear transport theme.
Genes
AAMDC, ANP32B, CBX5, CDK4, CKAP4, COMMD4, COQ2, CSE1L, DAZAP1, DEK, HDGF, IPO5, KPNB1, LSM4, MAD2L2, MZT2A, NRM, NUCKS1, PRKCSH, SAC3D1, SMARCA4, SMC1A, SNRPC, SSRP1, TFDP1, TRIM28, TUBB
Most correlated modules
- Nuclear Transport · correlation 0.92
- DNA Replication · correlation 0.89
- DNA Damage Repair · correlation 0.87
- Mitotic Cell Cycle · correlation 0.83
- mRNA Splicing · correlation 0.81
- NF-κB Oxidative Stress · correlation 0.81
- S-phase Proliferation · correlation 0.80
- Spliceosome snRNP Assembly · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.