FLNC — Filamin C
FLNC belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FLNC's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | YAP Mechanotransduction migration & adhesion | COBLL1, CREB5, DEPP1, DST, FGL2, FN1, GCNT2, GLIPR2 +7 more | View in SCUBA |
| Fibroblasts | Smooth Muscle Differentiation Developmental | ADCY5, ASB2, CABP1, CKB, DYSF, LIMS2, PGM5, TMEM35A | View in SCUBA |
| Smooth muscle cells | Costameric cytoskeleton Cytoskeletal | ACTR2, AOC3, APLP2, CTDSPL, GNG11, HSPG2, KANK2, NFIA +4 more | View in SCUBA |
About the gene
| Synonyms | ABP-280, ABPL, FLN2 |
|---|---|
| Chromosome | 7: 128830406-128859274 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters |
| Molecular function | Actin-binding |
Function
Muscle-specific filamin, which plays a central role in sarcomere assembly and organization. Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.