Costameric cytoskeleton
Gene co-expression module in Smooth muscle cells
| Category | Cytoskeletal |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
This is the only module in the batch with clear mural/smooth-muscle identity: FLNC (filamin C, myofibril anchoring), SNTA1 (syntrophin, dystrophin-glycoprotein complex), PGM5 (dystrophin-associated costamere protein), KANK2 (talin/focal-adhesion linker), ACTR2 (Arp2/3), plus basement-membrane and mural markers HSPG2 (perlecan), TMEM47, GNG11, AOC3/VAP-1 and PARM1. Together they describe the costameric/adhesion cytoskeleton that couples the contractile apparatus to the matrix rather than the contractile filaments themselves. Distinct from the housekeeping neighbors, it represents genuine SMC/pericyte state specificity.
Genes
ACTR2, AOC3, APLP2, CTDSPL, FLNC, GNG11, HSPG2, KANK2, NFIA, PARM1, PGM5, SNTA1, TMEM47
Most correlated modules
- Lysosomal-secretory processing · correlation 0.88
- Wnt-Hedgehog Niche · correlation 0.86
- Generic maintenance transcripts · correlation 0.85
- SMC Phenotype Regulation · correlation 0.84
- Adhesion Activation · correlation 0.77
- SMC Contractile Apparatus · correlation 0.75
- Post-translational regulators · correlation 0.74
- Fibroblast Matrisome · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.