AKR7A2 — Aldo-keto reductase family 7 member A2
AKR7A2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AKR7A2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Actin Cytoskeletal Organization Cytoskeletal | ACP1, ARL3, CAPZB, DERL1, GDE1, LEPROTL1, LIMS1, NPTN +8 more | View in SCUBA |
| Gamma-delta T cells | Complex I Assembly Mitochondrial & OxPhos | AP2S1, BLOC1S1, DCTN2, HSD17B10, LAMTOR2, MGMT, MRPL34, MRPL51 +13 more | |
| Innate lymphoid cells | Mitochondrial OxPhos Mitochondrial & OxPhos | ANXA6, AP2M1, ARL6IP4, ARPC1B, ATP5MC2, ATP5PB, BSG, CCNDBP1 +21 more | View in SCUBA |
| Macrophages | Mitotic Spindle Assembly Cell cycle | ACTL6A, ANP32E, BOLA3, BUB3, CCDC167, CENPW, CENPX, DCTPP1 +34 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cellular Housekeeping Housekeeping | ANP32A, ANXA5, AP1M1, APEX1, APOBEC3C, CDC26, DBNL, DCK +17 more | |
| Smooth muscle cells | Lysosomal Glycoprotein Catabolism Protein processing & ER | CERCAM, CPQ, FCGRT, GRN, HEXB, LTBP1, MRGPRF, PPIC | View in SCUBA |
About the gene
| Synonyms | AFAR |
|---|---|
| Chromosome | 1: 19303965-19312144 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Lipid metabolism |
Function
Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2- aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10- phenanthrenequinone (in vitro). Can reduce the dialdehyde protein- binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.