ILC Transcription Factor Program
Gene co-expression module in Innate lymphoid cells
| Category | Differentiation |
|---|---|
| Genes | 20 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
This weak-coherence module has ILC1 enrichment (2.1–4.1x). Hub genes include PHB2 (prohibitin 2, mitochondrial inner membrane/chromatin remodeling), RORC (RORγt, master transcription factor for ILC3/Th17 differentiation), SEC13 (COPII vesicle coat/nuclear pore), ZAP70 (T/NK cell signaling kinase), NFYC (transcription factor), ILK (integrin-linked kinase), DCTN2 (dynactin, cytoskeletal), MAP3K7 (TAK1, NF-κB/MAPK signaling), KDELR1 (ER retention receptor), MATN2 (extracellular matrix), APP (amyloid precursor), TOX (transcription factor for NK/T exhaustion/development), DEF6 (Rho GEF in T cells), LMAN1 (ER-Golgi cargo receptor), HSPB1 (heat shock protein). RORC and TOX are notable transcription factors for ILC/NK differentiation. ZAP70 and DEF6 are lymphocyte signaling molecules. The module appears to reflect a mixed ILC1 differentiation/signaling state with ER and cytoskeletal components. RORC and TOX together suggest ILC differentiation programming.
Genes
APP, DCTN2, DEF6, GRAMD1A, GRHPR, HSD17B12, HSPB1, ILK, KDELR1, LMAN1, MAP3K7, MATN2, MMP24OS, NFYC, PHB2, RORC, SEC13, SNRPA, TOX, ZAP70
Most correlated modules
- Cellular Metabolic Maintenance · correlation 0.94
- ILC1 Lymphocyte Signaling · correlation 0.92
- NK Cytotoxic Effector · correlation 0.92
- Mitochondrial Metabolic Housekeeping · correlation 0.90
- JAK-STAT Cytokine Signaling · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.