KDELR1 — KDEL endoplasmic reticulum protein retention receptor 1
KDELR1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KDELR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | ER-Golgi Trafficking Protein processing & ER | ALG5, CNIH4, HDDC3, ORMDL2, PYCARD, RAB8A, RASAL3, RBM42 +4 more | View in SCUBA |
| Fibroblasts | ER Protein Folding Housekeeping | AHCYL1, CANX, CSNK1A1, HNRNPK, HSP90B1, JAK1, KTN1, LAMTOR1 +10 more | View in SCUBA |
| Innate lymphoid cells | ILC Transcription Factor Program Differentiation | APP, DCTN2, DEF6, GRAMD1A, GRHPR, HSD17B12, HSPB1, ILK +11 more | View in SCUBA |
| Macrophages | Mixed Housekeeping Housekeeping | AP2M1, BAG1, CHMP4A, CISD2, COA6, CSNK2B, CYB5R3, DEGS1 +20 more | View in SCUBA |
About the gene
| Synonyms | ERD2, ERD2.1, HDEL |
|---|---|
| Chromosome | 19: 48382575-48391551 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
| Molecular function | Receptor |
| Biological process | ER-Golgi transport, Protein transport, Transport |
Function
Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.