HSD17B12 — Hydroxysteroid 17-beta dehydrogenase 12
HSD17B12 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HSD17B12's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Quiescent EC Identity Endothelial cell development | ADRB1, CAMK2D, CLU, CYP1B1, FAM20A, FOXP1, FZD6, GCHFR +19 more | View in SCUBA |
| Enterocytes | Transit-amplifying progenitor Epithelial development | CCND2, CLINT1, EHF, ELOVL6, MSI2, PKP2, RBM3, SLC38A1 | View in SCUBA |
| Innate lymphoid cells | ILC Transcription Factor Program Differentiation | APP, DCTN2, DEF6, GRAMD1A, GRHPR, HSPB1, ILK, KDELR1 +11 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic Vascular Stability endothelial development | GJA1, GLT8D2, HIC1, IGFBP4, KCTD12, MAF, ROBO4, S1PR1 +6 more | View in SCUBA |
| Macrophages | ER-Lysosome Trafficking Vesicular traficking | BPNT2, CALU, CLPTM1L, CTSB, DHRS7, EMC10, GBA1, GNS +21 more | View in SCUBA |
About the gene
| Synonyms | KAR, SDR12C1 |
|---|---|
| Chromosome | 11: 43680680-43856617 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Oxidoreductase |
| Biological process | Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis |
Function
Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3- hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.