HSPB1 — Heat shock protein family B (small) member 1

HSPB1 belongs to a gene co-expression module in 13 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

HSPB1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Heat Shock Response Stress	BAG3, CHORDC1, DDIT4, DEDD2, DNAJA4, DNAJB1, DNAJB4, DNAJB6 +13 more	View in SCUBA
CD4⁺ T cells	Chaperone Proteostasis Protein processing & ER	BANF1, CCT3, CCT4, CCT5, FXR1, HNRNPH3, MAGOH, NUDC +7 more	View in SCUBA
CD8⁺ T cells	Heat Shock Response Stress	DNAJA4, DNAJB1, DNAJB4, HSPA1A, HSPA1B, HSPA6, PLIN2, RGS2 +3 more	View in SCUBA
Enterocytes	Surface colonocyte transport Absorption	CA4, CD46, CITED1, CLCN1, DOCK4, GSN, ITM2C, LYPD8 +4 more	View in SCUBA
Gamma-delta T cells	ER/Osmotic Stress Stress	ABHD3, DNAJA4, FKBP4, HIBCH, HSD17B7, HSPA4, MBNL2, MRPL18 +7 more
Goblet cells	Heat Shock Response Stress	DNAJA1, EIF1AX, EIF5, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, HSPA8 +5 more	View in SCUBA
Hematopoietic progenitor cells	Metabolic Housekeeping Housekeeping	CRYGD, EBPL, HINT1, LSM7, PCBD1, PPA1, TALDO1, YBX3
Innate lymphoid cells	ILC Transcription Factor Program Differentiation	APP, DCTN2, DEF6, GRAMD1A, GRHPR, HSD17B12, ILK, KDELR1 +11 more	View in SCUBA
Lymphatic endothelial	Heat Shock Response Stress	BAG3, DNAJB1, DNAJB4, HSP90AA1, HSPA1A, HSPA1B, HSPA6, HSPE1 +3 more	View in SCUBA
Monocytes	Co-chaperone Proteostasis Stress	AHSA1, ALAS1, BAG3, CACYBP, FBXL14, FKBP4, HSPA6, SERPINH1 +2 more	View in SCUBA
Mucosal-associated invariant T cell	Heat Shock Response Stress	AHSA1, BAG3, CACYBP, CAPG, CHORDC1, CSF1, DNAJA4, DNAJB4 +13 more
Natural Killer cells	Inducible HSP70 Stress Stress	BAG3, DNAJB1, FKBP4, HSPA1A, HSPA1B, HSPA4, HSPA6, RHOB +2 more	View in SCUBA
Smooth muscle cells	Calcium Handling Contractile Contractility	CALM2, COX7A2, EIF4A2, PLN, PPDPF, UQCRB, YBX1	View in SCUBA

About the gene

Synonyms	CMT2F, Hs.76067, Hsp25, HSP27, HSP28
Chromosome	7: 76302673-76304295
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Molecular function	Chaperone
Biological process	Host-virus interaction, Stress response

Function

Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.