Oxidative Phosphorylation
Gene co-expression module in Colonocytes
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 30 genes have a known function matching the annotation |
Why this annotation
Hub genes include MGST3 (microsomal glutathione S-transferase), MPC1 (mitochondrial pyruvate carrier 1), COX6B1, COX6A1, COX5B, COX7A2, COX8A (Complex IV/cytochrome c oxidase subunits), NDUFB3, NDUFA1 (Complex I subunits), UQCR11 (Complex III), ATP5ME, ATP5PF (Complex V/ATP synthase subunits), MRPS36 (mitoribosome small subunit), DECR1 (2,4-dienoyl-CoA reductase, mitochondrial fatty acid oxidation), LAMTOR1 (Ragulator/lysosomal mTOR), AP2M1 (clathrin adaptor), DCTN2 (dynactin), BCAP31 (ER/apoptosis), HINT1 (histidine triad nucleotide binding), UBE2D2 (ubiquitin conjugating enzyme). The dominant program is OxPhos (Complex I, III, IV, V subunits) plus MPC1 for pyruvate import. This is a companion OxPhos module to M24, with more Complex IV subunits. Decreased in CD inflammation, restored with CD treatment.
Genes
Most correlated modules
- Oxidative Phosphorylation · correlation 0.93
- Complex IV Assembly · correlation 0.91
- Oxidative Phosphorylation · correlation 0.91
- Proteasome Activity · correlation 0.91
- Mitochondrial Peroxisomal Metabolism · correlation 0.86
- Proteasome Assembly · correlation 0.85
- Mitochondrial OxPhos · correlation 0.85
- ER-Golgi Trafficking · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.