Complex I Assembly
Gene co-expression module in Gamma-delta T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 22 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 22 genes have a known function matching the annotation |
Why this annotation
Hub genes are strongly enriched for mitochondrial Complex I subunits: NDUFS6, NDUFS7, NDUFB3, NDUFA7 (four NADH dehydrogenase subunits). Additional genes include MRPL51/MRPL34 (mitochondrial ribosome), TALDO1 (pentose phosphate pathway), PSMB3 (proteasome), LAMTOR2 (lysosomal mTOR signaling), RBX1 (SCF ubiquitin ligase), AP2S1 (clathrin-mediated endocytosis), POLD4 (DNA polymerase delta). The module is core coherence with multiple NADH dehydrogenase subunits as top hubs, clearly identifying this as a mitochondrial oxidative phosphorylation / Complex I module. The highest certainty in the batch.
Genes
AKR7A2, AP2S1, BLOC1S1, DCTN2, HSD17B10, LAMTOR2, MGMT, MRPL34, MRPL51, NAA38, NDUFA7, NDUFB3, NDUFS6, NDUFS7, NUDCD2, PGLS, PNKD, POLD4, PSMB3, RBX1, RPUSD3, TALDO1
Most correlated modules
- Transcriptional Elongation Control · correlation 0.90
- General Housekeeping Mixed · correlation 0.89
- Cellular Homeostasis · correlation 0.89
- Mitoribosome Small Subunit · correlation 0.89
- Glycolysis & Proteasome · correlation 0.88
- Mitochondrial Translation · correlation 0.88
- Oxidative Phosphorylation · correlation 0.88
- Endosomal Vesicle Trafficking · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.