DDX23 — DEAD-box helicase 23
DDX23 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DDX23's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Metabolic-Translational Coupling RNA processing & translation | APOL6, ARCN1, ARGLU1, DCAF12, EIF2S1, EIF4G1, FHOD1, GMPPB +20 more | |
| Mucosal-associated invariant T cell | Vesicle Membrane Trafficking Housekeeping | ACSL5, AP2B1, APOBR, CAPRIN1, CAPZA1, G3BP1, IARS1, PITPNB +6 more |
About the gene
| Synonyms | prp28, PRPF28, SNRNP100, U5-100KD |
|---|---|
| Chromosome | 12: 48829756-48852842 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Predicted intracellular proteins |
| Molecular function | Helicase, Hydrolase |
| Biological process | mRNA processing, mRNA splicing |
Function
Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.