PITPNB — Phosphatidylinositol transfer protein beta
PITPNB belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PITPNB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | Basement Membrane ECM migration & adhesion | BRD4, COL4A1, COL4A2, GOLGA4, ITGAV, PXDN, RAI14, RB1CC1 +4 more | View in SCUBA |
| Macrophages | Transcriptional Regulation Housekeeping | CCSER2, CUX1, ECPAS, EPB41L3, FUBP1, GATAD2A, GNA12, LRRFIP2 +10 more | View in SCUBA |
| Mucosal-associated invariant T cell | Vesicle Membrane Trafficking Housekeeping | ACSL5, AP2B1, APOBR, CAPRIN1, CAPZA1, DDX23, G3BP1, IARS1 +6 more |
About the gene
| Synonyms | VIB1B |
|---|---|
| Chromosome | 22: 27851669-27920134 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Lipid transport, Transport |
Function
Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes. Also catalyzes the transfer of sphingomyelin (By similarity). Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.