Vesicle Membrane Trafficking
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Housekeeping |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 15 genes have a known function matching the annotation |
Why this annotation
This module contains RAB5B (early endosome trafficking), RAB27A (secretory lysosome/granule exocytosis), AP2B1 (clathrin-mediated endocytosis adaptor), CAPRIN1 (stress granule assembly), G3BP1 (stress granule nucleator), SSR1 (translocon-associated signal recognition), PITPNB (phosphatidylinositol transfer, vesicle budding), APOBR (lipid/receptor trafficking), ACSL5 (fatty acid activation), TRIM56 (innate immune ubiquitin ligase), SLAMF7 (NK/T cell activating receptor), PTK2B (FAK2, integrin/cytoskeletal signaling), DDX23 (RNA helicase/spliceosome), CAPZA1 (actin capping), and IARS1 (aminoacyl-tRNA synthetase). The dominant theme is intracellular vesicle/membrane trafficking centered on RAB GTPases, clathrin endocytosis, and secretory pathway components, with accessory stress granule and cytoskeletal elements. SLAMF7 and RAB27A suggest cytotoxic granule/exosome secretion context in MAIT cells. No clear contamination or single-lineage artifact. The module is best described as vesicle/membrane trafficking.
Genes
ACSL5, AP2B1, APOBR, CAPRIN1, CAPZA1, DDX23, G3BP1, IARS1, PITPNB, PTK2B, RAB27A, RAB5B, SLAMF7, SSR1, TRIM56
Most correlated modules
- Chromatin Remodeling · correlation 0.94
- Oxidative Stress Response · correlation 0.93
- RNA Splicing Processing · correlation 0.91
- Epigenetic Maintenance · correlation 0.91
- Chromatin Remodeling · correlation 0.88
- Lymphocyte Survival · correlation 0.87
- Histone Modification · correlation 0.84
- Cellular Housekeeping · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.