Metabolic-Translational Coupling
Gene co-expression module in Gamma-delta T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 29 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 14 of 29 genes have a known function matching the annotation |
Why this annotation
Hub genes include PPP4R3B (PP4 phosphatase regulatory subunit, involved in DNA repair/ribosome biogenesis), NOLC1 (nucleolar and coiled-body phosphoprotein, ribosome biogenesis), IARS1 (isoleucyl-tRNA synthetase, aminoacylation), MAP4K1/HPK1 (T cell signaling kinase, downstream of TCR), EIF2S1 (eIF2alpha, global translation initiation), PRKAA1 (AMPK alpha, cellular energy sensor), NOP14 (ribosome biogenesis), PIK3CG (PI3K gamma, T cell/immune signaling), EIF4G1 (cap-dependent translation initiation), DDX23 (U5 snRNP helicase, splicing), SF3B1 (spliceosome), ARCN1 (COPI vesicle coat). Strong coherence. The dominant theme is translational control and ribosome biogenesis (IARS1, EIF2S1, EIF4G1, NOP14, NOLC1) integrated with metabolic/energy sensing (PRKAA1/AMPK). AMPK phosphorylates eIF2B and other translation regulators, making this a coherent metabolic-translational coupling program. APOL6 and PPRC1 (PGC1-related) add metabolic flavor.
Genes
APOL6, ARCN1, ARGLU1, DCAF12, DDX23, EIF2S1, EIF4G1, FHOD1, GMPPB, GPI, IARS1, MAP4K1, MDC1, MON1B, NEK9, NOLC1, NOP14, PHF8, PIK3CG, POLR2D, PPP4R3B, PPP5C, PPRC1, PRKAA1, PRPS1, SAFB, SF3B1, TUT7, WAPL
Most correlated modules
- Chromatin Remodeling · correlation 0.87
- Actin Cytoskeletal Regulation · correlation 0.87
- DNA Damage Response · correlation 0.87
- Post-transcriptional RNA Regulation · correlation 0.86
- Vesicular Trafficking · correlation 0.84
- NK/T Cell Identity · correlation 0.83
- Rho GTPase Signaling · correlation 0.83
- Chromatin Epigenetic Regulation · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.