DPY30 — Dpy-30 histone methyltransferase complex regulatory subunit
DPY30 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DPY30's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Chaperone Protein Folding Protein processing & ER | AAMP, AHCYL1, CCT7, CCT8, CHMP5, COX17, EIF2S2, GHITM +16 more | |
| Innate lymphoid cells | RNA Processing & Proteostasis RNA processing & translation | ATP5PD, CIRBP, COPS6, MORF4L1, MYDGF, PDIA6, PNISR, POLR2J +5 more | View in SCUBA |
About the gene
| Synonyms | Cps25, HDPY-30, Saf19 |
|---|---|
| Chromosome | 2: 31867809-32039805 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Chromatin regulator |
| Biological process | Transcription, Transcription regulation |
Function
As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.