Chaperone Protein Folding
Gene co-expression module in Gamma-delta T cells
| Category | Protein processing & ER |
|---|---|
| Genes | 25 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 25 genes have a known function matching the annotation |
Why this annotation
Hub genes include PFDN6 (prefoldin chaperone subunit), CCT7 and CCT8 (chaperonin-containing TCP-1 complex subunits), EIF2S2 (eukaryotic translation initiation factor), PA2G4 (ribosome biogenesis/proliferation-associated), MRPL52 (mitoribosome), NDUFB1/NDUFA3/COX17 (mitochondrial respiratory chain). The module combines chaperone-assisted protein folding (prefoldin/CCT complex), translation initiation, and mitochondrial respiratory chain components. The dominant functional identity is cytosolic chaperone-mediated protein folding given multiple CCT/prefoldin subunits as top hubs. Neighbor modules also show mixed housekeeping programs.
Genes
AAMP, AHCYL1, CCT7, CCT8, CHMP5, COX17, DPY30, EIF2S2, GHITM, LPXN, MCTS1, MITD1, MLEC, MRPL52, MYCBP, NDUFA3, NDUFB1, PA2G4, PEF1, PFDN6, POLR2L, RAD23A, SKIC8, SNRPE, TMBIM6
Most correlated modules
- Mitochondrial Translation · correlation 0.90
- Mitochondrial Housekeeping · correlation 0.86
- Mitoribosome Small Subunit · correlation 0.85
- Oxidative Phosphorylation · correlation 0.84
- Basal Cell Maintenance · correlation 0.84
- Complex I Assembly · correlation 0.83
- Glycolysis & Proteasome · correlation 0.82
- Endosomal Vesicle Trafficking · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.