MYDGF — Myeloid derived growth factor
MYDGF belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MYDGF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | ER stress UPR Protein processing & ER | CCT2, CDK2AP2, CRELD2, DDX39A, DNAJB11, DSTN, EIF5A, GPSM3 +9 more | View in SCUBA |
| Endothelial | UPR / ER Stress Protein processing & ER | CALR, CANX, CTSB, CTTN, GRN, HDLBP, HSP90B1, HSPA5 +10 more | View in SCUBA |
| Fibroblasts | ER-Golgi Trafficking Vesicular traficking | ARL1, CALR, COPE, DNAJC3, EMC7, GDI2, MPG, PDIA6 +6 more | View in SCUBA |
| Goblet cells | Mucin Folding Machinery Mucus production & secretion | AGR2, KDELR2, OSTC, PPIB, SEC11C, SEC61B, SEC61G, SSR3 | View in SCUBA |
| Innate lymphoid cells | RNA Processing & Proteostasis RNA processing & translation | ATP5PD, CIRBP, COPS6, DPY30, MORF4L1, PDIA6, PNISR, POLR2J +5 more | View in SCUBA |
| Macrophages | ERAD Proteasome Housekeeping | ADRM1, EIF6, EMC6, GLRX3, GNPTG, LRPAP1, MAP2K2, MED8 +16 more | View in SCUBA |
| Pericytes | ER Protein Folding Stress | AP2S1, CALU, DYNLT1, IKBIP, KDELR2, OSTC, P4HB, PPIB +1 more | View in SCUBA |
About the gene
| Synonyms | C19orf10, IL-25, IL-27, IL25, IL27, IL27w, R33729_1, SF20 |
|---|---|
| Chromosome | 19: 4641374-4670362 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Angiogenesis, Apoptosis |
Function
Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.