CCT8 — Chaperonin containing TCP1 subunit 8
CCT8 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCT8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | OxPhos & Proteasome Mitochondrial & OxPhos | ENY2, LSM8, NDUFC2, NDUFV2, PPM1G, PSMC5, PSMD7, SAP18 +1 more | View in SCUBA |
| Endothelial | ER-Golgi Trafficking Protein processing & ER | ARPC1A, FIBP, GDI2, GGCT, LMAN2, MAP2K2, MRPS16, PAICS +10 more | View in SCUBA |
| Gamma-delta T cells | Chaperone Protein Folding Protein processing & ER | AAMP, AHCYL1, CCT7, CHMP5, COX17, DPY30, EIF2S2, GHITM +16 more | |
| Innate lymphoid cells | Proteasome & COPI Trafficking Protein processing & ER | COPE, COPZ1, COX5A, FIBP, GPX4, LAMTOR4, MDH1, NDUFC2 +5 more | View in SCUBA |
| Macrophages | Spliceosomal snRNP Cell cycle | ANAPC11, BANF1, CCDC25, ERH, FIBP, FKBP3, GLRX5, IER3IP1 +30 more | View in SCUBA |
About the gene
| Synonyms | C21orf112, Cctq, PRED71 |
|---|---|
| Chromosome | 21: 29055805-29073797 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Chaperone, Hydrolase |
Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.