POLR2J — RNA polymerase II subunit J
POLR2J belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
POLR2J's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Vesicular trafficking Housekeeping | ACSL4, ARL8B, BLOC1S2, C3orf38, DTX3L, EFCAB14, GGA2, HMGXB3 +17 more | View in SCUBA |
| CD8⁺ T cells | Proteasome Degradation Housekeeping | ARPP19, CLTA, GNG5, HSBP1, NDUFB4, POLR2K, PSMB2, PSMB3 +2 more | View in SCUBA |
| Gamma-delta T cells | Protein Homeostasis Chaperones Housekeeping | ATXN10, DYNLRB1, GMFG, HIGD1A, NAA10, PPIA, PPIB, PRDX2 +6 more | |
| Innate lymphoid cells | RNA Processing & Proteostasis RNA processing & translation | ATP5PD, CIRBP, COPS6, DPY30, MORF4L1, MYDGF, PDIA6, PNISR +5 more | View in SCUBA |
About the gene
| Synonyms | hRPB14, POLR2J1, RPB11, RPB11A, RPB11m |
|---|---|
| Chromosome | 7: 102473128-102478922 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted intracellular proteins, RNA polymerase related proteins |
| Biological process | Transcription |
Function
Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.