RNA Processing & Proteostasis
Gene co-expression module in Innate lymphoid cells
| Category | RNA processing & translation |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include PNISR (pre-mRNA splicing factor), POLR2J (RNA polymerase II subunit), SNRPN (snRNP component, splicing), MORF4L1 (chromatin remodeling/HDAC complex), DPY30 (histone H3K4 methylation), CIRBP (cold-inducible RNA binding protein, stress-responsive RNA processing), SUMO3 (SUMOylation, connects to neighbor M77), PDIA6 (ER protein disulfide isomerase), PSMC5 (proteasome regulatory subunit), COPS6 (COP9 signalosome, protein degradation). The module combines RNA processing (PNISR, POLR2J, SNRPN, CIRBP) with protein quality control (PSMC5, COPS6, SUMO3, PDIA6). Moderate coherence with many weak membership scores reflects this mixed program. Neighbor to M77 (SUMOylation) reinforces the protein homeostasis theme.
Genes
ATP5PD, CIRBP, COPS6, DPY30, MORF4L1, MYDGF, PDIA6, PNISR, POLR2J, PSMC5, SNRPN, SUMO3, TSTD1, UGP2
Most correlated modules
- Mitochondrial Metabolism · correlation 0.94
- Lipid & Isoprenoid Metabolism · correlation 0.94
- RNA Splicing Processing · correlation 0.94
- Actin Cytoskeleton Remodeling · correlation 0.93
- SUMOylation Program · correlation 0.92
- ILC-1 identity · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.