COX17 — Cytochrome c oxidase copper chaperone COX17

COX17 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

COX17's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	OxPhos & proteasome Mitochondrial & OxPhos	CCDC167, CLTA, COX5A, DBI, FKBP1A, FMNL1, GALM, MRPL41 +10 more	View in SCUBA
CD8⁺ T cells	Metabolic Housekeeping Housekeeping	DAZAP1, EIF4E, ILF2, MRPL51, NDUFA2, SSNA1, TADA3, TPM4	View in SCUBA
Gamma-delta T cells	Chaperone Protein Folding Protein processing & ER	AAMP, AHCYL1, CCT7, CCT8, CHMP5, DPY30, EIF2S2, GHITM +16 more
Goblet cells	Metabolic Stress Response Mitochondrial & OxPhos	ATP6V0B, C11orf24, CHCHD2, LDHA, MRPL52, PRDX4, SRA1, TAGLN2 +2 more	View in SCUBA
Innate lymphoid cells	Mixed Proteostasis Metabolism Metabolism	ADRM1, ANXA11, ATP6V0B, CISD2, DNAJC8, DR1, EIF3I, HPRT1 +18 more	View in SCUBA
Lymphatic endothelial	Apoptosis Immune Regulation Immune regulation	A4GALT, CFLAR, GRINA, MPZL1, NINJ1, OPTN, PAWR, RCN1 +2 more	View in SCUBA
Macrophages	Protein Homeostasis Mixed Housekeeping	ABRACL, ADI1, AP2S1, ATP5F1B, BRK1, CFL1, CHCHD2, CLTA +33 more	View in SCUBA
Pericytes	Mitochondrial OxPhos Mitochondrial & OxPhos	ATP1B3, ATP5PF, CALM1, CAPZA2, COX5A, MRPL33, SRP14, TSPO	View in SCUBA
Smooth muscle cells	Basal Metabolic Housekeeping Housekeeping	ARPC2, C11orf58, C1orf43, C4orf3, CNBP, GUK1, HNRNPDL, HNRNPH2 +6 more	View in SCUBA

About the gene

Chromosome	3: 119654513-119677454
Predicted location	Intracellular
Essential gene	Yes
Protein class	Cancer-related genes, Essential proteins, Predicted intracellular proteins
Molecular function	Chaperone

Function

Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.