GHITM — Growth hormone inducible transmembrane protein
GHITM belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GHITM's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Spliceosome snRNP RNA processing | CHCHD2, COX7B, MAGOH, PPIA, RAN, SNRPB, SNRPC, SNRPD1 +4 more | View in SCUBA |
| CD4⁺ T cells | mRNA Processing RNA processing | ABI1, AGFG1, CCND3, CD164, CHMP2B, DBF4, HNRNPL, LSM1 +9 more | View in SCUBA |
| CD8⁺ T cells | Vesicle Trafficking Protein processing & ER | AP2M1, ARF1, CDC37, EWSR1, GNB2, LMAN2, PPP2CA, RAB11B +1 more | View in SCUBA |
| Enterocytes | Abundant Transcript Baseline Housekeeping | ATP5IF1, C15orf48, CALM2, CHCHD2, CSTB, KRT8, LGALS3, MPC2 +6 more | View in SCUBA |
| Gamma-delta T cells | Chaperone Protein Folding Protein processing & ER | AAMP, AHCYL1, CCT7, CCT8, CHMP5, COX17, DPY30, EIF2S2 +16 more | |
| Goblet cells | Ubiquitin-Proteasome Degradation Housekeeping | ARPC5, GAPDH, PSMA7, PSMB3, PSMB6, RHOA, TALDO1, UBE2L3 | View in SCUBA |
| Macrophages | Proteasome UPS Housekeeping | ATP6V1D, ATP6V1E1, BAX, C1orf43, COX7A2L, DCUN1D5, DNAJC15, DNAJC8 +28 more | View in SCUBA |
About the gene
| Synonyms | DERP2, HSPC282, My021, PTD010, TMBIM5 |
|---|---|
| Chromosome | 10: 84139482-84154841 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
| Biological process | Apoptosis |
Function
Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport. Mediates proton-dependent calcium efflux from mitochondrion. Also functions as an electroneutral mitochondrial proton/potassium exchanger. Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c. Inhibits the proteolytic activity of AFG3L2, stimulating respiration and stabilizing respiratory enzymes in actively respiring mitochondria. However, when mitochondria become hyperpolarized, GHITM loses its inhibitory activity toward AFG3L2 and the now the active AFG3L2 turns first on GHITM and, if hyperpolarization persists, on other proteins of the mitochondria, leading to a broad remodeling of the mitochondrial proteome.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.