B-cell signaling regulators
Gene co-expression module in CD19⁺ B cells
| Category | B cell maturation |
|---|---|
| Genes | 12 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes are a mix of signaling and chromatin/RNA regulators: ITSN2 (endocytic adaptor), EHMT1/KMT2A (histone methyltransferases), CDK13 (transcriptional CDK), WIPF1/FNBP1/ACAP2 (actin/cytoskeleton and membrane trafficking), ST6GAL1 (glycosylation), TUT7 (RNA uridylation), JAK1 (cytokine signaling), UBE2H (ubiquitin), BCL2L11/BIM (apoptosis). This is a broadly distributed, lowly-detected module of B-cell housekeeping/signaling genes without a single dominant program. Coherence is core but biologically heterogeneous, with several chromatin and signaling regulators of B-cell homeostasis. No contamination (uniform). Best described as general B-cell signaling/maturation regulation.
Genes
ACAP2, BCL2L11, CDK13, EHMT1, FNBP1, ITSN2, JAK1, KMT2A, ST6GAL1, TUT7, UBE2H, WIPF1
Most correlated modules
- B Cell Identity Signaling · correlation 0.88
- Germinal center B-cell · correlation 0.87
- Chromatin modifiers · correlation 0.86
- B-cell activation signaling · correlation 0.84
- Dark-zone GC B-cell · correlation 0.80
- MHC-II antigen presentation · correlation 0.78
- mRNA splicing · correlation 0.77
- BCR Signaling Regulation · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.